Peyronies Disease

Every man’s penis is different. They vary in size and shape. It might even be normal to have a slight curve in your penis. But if you notice a significant bend has formed when your penis is erect, it’s time to ask a urologist if it could be Peyronie’s disease.

Symptoms of Peyronies Disease

If you have Peyronie’s disease, you may notice one or more of these symptoms:

  • A curved erection with or without pain If you develop a curve in your erection that you didn’t notice before, it may be a sign that you could have Peyronie’s disease. Some men report they feel pain in their erection as the curve develops for the first 12 to 18 months.
  • A Peyronie’s plaque This is a bump of scar tissue under the skin of the penis. It’s most commonly found on the top side of the penis. Some men can feel it, while others don’t notice it.
  • Bothered by your erection Many men with Peyronie’s disease report being bothered by the way their curved erection looks and the challenges it presents to their ability to engage in sexual activity.

What is XIAFLEX®?

XIAFLEX® is a prescription medicine used to treat adult men with Peyronie’s disease who have a “plaque” that can be felt and a curve in their penis greater than 30 degrees when treatment is started. It is not known if XIAFLEX® is safe and effective in children under the age of 18.

Due to the symptoms of Peyronie’s disease and the way XIAFLEX® has been studied, you need to have the following 2 symptoms in order to start treatment with XIAFLEX®:

  • A PEYRONIE’S PLAQUE – A bump of scar tissue under the skin of the penis that can be felt
  • A CURVED ERECTION – Bent at least 30 degrees at the start of treatment
Starting your treatment

Treatment involves a series of injections given by trained urologists in their office. When paired with gentle stretching and straightening of the penis, XIAFLEX® is proven to help reduce erectile curvature.

  • Visit 1: First injection of XIAFLEX®
    Your healthcare professional (HCP) will inject XIAFLEX® into the plaque that is causing your penis to curve• XIAFLEX® is given as part of a treatment cycle. In each treatment cycle, you will receive an injection of XIAFLEX®, followed by a second injection 1 to 3 days later.
  • Visit 2; Second injection of XIAFLEX®
    Occurs 1 to 3 days after initial injection
  • Visit 3: HCP penile modeling
    1 to 3 days after the second injection of XIAFLEX®, you will need to return to your HCP’s office for a manual procedure called penile modeling that will stretch and help straighten your penis
Your role at home

Daily penile modeling

  • After each treatment cycle, you will need to take a few minutes each day to perform at-home stretching and straightening activities on your penis for about 6 weeks
  • To find out how to perform these activites, see the daily penile modeling activities section on pages 8 and 9 of this brochure

Sexual activity

For each treatment cycle, do not have sex or engage in any other sexual activity:

  • Between the first and second injections
  • For at least 4 weeks after the second injection and after any pain and swelling has gone away

After each injection

  • Your penis may be wrapped with a bandage. Your HCP will tell you when to take the bandage off
  • It’s common to see bruising and swelling after your injections with XIAFLEX®
  • Avoid situations that may cause you to strain your stomach (abdominal) muscles, such as straining during bowel movements
  • Do not use a vacuum erection device during your treatment with XIAFLEX®
Your role during treatment

Part of your commitment to treatment means performing the 2 types of penile modeling activities (stretching and straightening) at home daily for 6 weeks at the end of each treatment cycle.

Stretching Activity

Gently stretch your penis 3 times a day. Only stretch your penis if your penis is not hard (erect).

  1. With one hand, hold the tip of your penis with your fingers. With your other hand, hold the base of your penis with your fingers.
  2. Gently pull your penis away from your body to its full length and hold the stretch for 30 seconds.
  3. Let go of the tip of your penis and let your penis return to its normal length.

Straightening Activity

Gently straighten your penis once a day. Only straighten your penis if you have an erection that happens without any sexual activity (spontaneous erection). Bending your penis should not cause any pain or discomfort.

  1. With one hand, hold your erect penis.
  2. With your other hand, gently bend your penis in the opposite direction of the curve.
  3. Hold the penis in this more straightened position for 30 seconds, then let go.

XIAFLEX® can cause serious side effects, including penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX® may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX®, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.

What do I need to know before my first visit?

Read Frequently Asked Questions to learn more

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